Motif ID: RXR{A,B,G}.p2

Z-value: 1.652


Transcription factors associated with RXR{A,B,G}.p2:

Gene SymbolEntrez IDGene Name
RXRA 6256 retinoid X receptor, alpha
RXRB 6257 retinoid X receptor, beta
RXRG 6258 retinoid X receptor, gamma

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RXRGchr1_-_163680941-0.656.9e-03Click!
RXRAchr9_+_1363581450.533.6e-02Click!
RXRBchr6_-_332761410.467.5e-02Click!


Activity profile for motif RXR{A,B,G}.p2.

activity profile for motif RXR{A,B,G}.p2


Sorted Z-values histogram for motif RXR{A,B,G}.p2

Sorted Z-values for motif RXR{A,B,G}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RXR{A,B,G}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr22_+_18081968 3.131 NM_002688
 SEPT5
septin 5
chr6_+_43846372 2.604 VEGFA
vascular endothelial growth factor A
chr6_+_43845915 2.188 NM_001025366
NM_001025367
NM_001025368
NM_001025369
NM_001025370
NM_001033756
NM_001171622
NM_001171623
NM_001171624
NM_001171625
NM_001171626
NM_001171627
NM_001171628
NM_001171629
NM_001171630
NM_003376
 VEGFA















vascular endothelial growth factor A















chr22_+_18085891 2.173 SEPT5
septin 5
chr22_+_18085990 2.131 SEPT5-GP1BB
SEPT5
SEPT5-GP1BB read-through transcript
septin 5
chr6_+_43845875 1.911 VEGFA
vascular endothelial growth factor A
chr6_+_43846155 1.816 VEGFA
vascular endothelial growth factor A
chr9_-_101621964 1.781


chr18_+_75261231 1.674 NM_172387
NM_172389
 NFATC1

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1

chr20_+_60558369 1.623 C20orf166
chromosome 20 open reading frame 166
chr6_+_43846735 1.621 VEGFA
vascular endothelial growth factor A
chr20_-_61933012 1.611 ZBTB46
zinc finger and BTB domain containing 46
chr1_+_9571518 1.526 NM_001010866
NM_001130924
 TMEM201

transmembrane protein 201

chr22_+_48966394 1.509 TRABD
TraB domain containing
chr17_+_7125702 1.473 NM_001042
 SLC2A4
solute carrier family 2 (facilitated glucose transporter), member 4
chr11_-_75595098 1.397 NM_004626
 WNT11
wingless-type MMTV integration site family, member 11
chr17_+_34115383 1.312 NM_005937
 MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr5_+_139040479 1.293 CXXC5
CXXC finger protein 5
chr22_+_48966480 1.273 NM_025204
 TRABD
TraB domain containing
chr1_-_38285033 1.266 NM_002699
 POU3F1
POU class 3 homeobox 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 59 entries
enrichment   p-value GO term description
2.15 3.03e-03 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter
1.89 3.66e-05 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.86 1.07e-06 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.78 6.62e-03 GO:0001501 skeletal system development
1.71 1.09e-03 GO:0032583 regulation of gene-specific transcription
1.63 2.68e-04 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.62 4.37e-08 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.62 2.57e-04 GO:0045893 positive regulation of transcription, DNA-dependent
1.61 5.34e-04 GO:0051172 negative regulation of nitrogen compound metabolic process
1.61 2.56e-03 GO:0051253 negative regulation of RNA metabolic process
1.61 3.25e-03 GO:0045892 negative regulation of transcription, DNA-dependent
1.60 1.93e-04 GO:0010628 positive regulation of gene expression
1.58 1.42e-03 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.57 1.15e-03 GO:0051254 positive regulation of RNA metabolic process
1.57 1.51e-03 GO:0010558 negative regulation of macromolecule biosynthetic process
1.56 1.46e-03 GO:0031327 negative regulation of cellular biosynthetic process
1.56 4.90e-03 GO:0010629 negative regulation of gene expression
1.54 2.59e-03 GO:0009890 negative regulation of biosynthetic process
1.53 2.83e-03 GO:0009790 embryo development
1.52 1.79e-03 GO:0010557 positive regulation of macromolecule biosynthetic process

Gene overrepresentation in compartment category:

Showing 1 to 15 of 15 entries
enrichment   p-value GO term description
1.67 2.28e-02 GO:0015629 actin cytoskeleton
1.58 4.71e-02 GO:0048471 perinuclear region of cytoplasm
1.25 1.31e-03 GO:0031974 membrane-enclosed lumen
1.25 1.96e-02 GO:0031981 nuclear lumen
1.24 3.46e-03 GO:0043233 organelle lumen
1.24 1.04e-02 GO:0044428 nuclear part
1.23 8.96e-03 GO:0070013 intracellular organelle lumen
1.15 1.73e-04 GO:0044422 organelle part
1.15 2.98e-04 GO:0044446 intracellular organelle part
1.09 9.26e-03 GO:0043231 intracellular membrane-bounded organelle
1.09 1.16e-02 GO:0043227 membrane-bounded organelle
1.08 1.11e-02 GO:0043226 organelle
1.08 1.11e-02 GO:0043229 intracellular organelle
1.07 3.23e-03 GO:0044424 intracellular part
1.06 6.67e-03 GO:0005622 intracellular

Gene overrepresentation in function category:

Showing 1 to 7 of 7 entries
enrichment   p-value GO term description
1.75 5.33e-09 GO:0043565 sequence-specific DNA binding
1.67 1.86e-02 GO:0016563 transcription activator activity
1.59 2.92e-08 GO:0001071 nucleic acid binding transcription factor activity
1.59 2.92e-08 GO:0003700 sequence-specific DNA binding transcription factor activity
1.53 8.38e-07 GO:0030528 transcription regulator activity
1.25 2.85e-03 GO:0003677 DNA binding
1.13 5.60e-05 GO:0005515 protein binding